N-bromobutanimide → 3,6,8-Tribromoimidazo[1,2-a]pyrazine

HRID 1809198노트

반응식

HRID 1809198 반응식
[Br:1]N1C(=O)CCC1=O.[Br:9][C:10]1[N:11]=[C:12]([Br:19])[C:13]2[N:14]([CH:16]=[CH:17][N:18]=2)[CH:15]=1>ClCCl>[Br:1][C:16]1[N:14]2[CH:15]=[C:10]([Br:9])[N:11]=[C:12]([Br:19])[C:13]2=[N:18][CH:17]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

생성물 1

HCID 142076223,6,8-Tribromoimidazo[1,2-a]pyrazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

N-bromosuccinimide (1.81 g, 10.15 mmol) was added to a solution of 6,8-Dibromo-imidazo[1,2-a]pyrazine (2.0 g, 10.15 mmol) in dichloromethane (40 ml). The reaction was stirred at room temperature over night then diluted with dichloromethane (100 ml) and washed with saturated aqueous sodium hydrogen carbonate (2×50 ml) and brine (50 ml). The organic layer was dried (MgSO4), filtered and concentrated in vaccuo. The product, 3,6,8-Tribromo-imidazo[1,2-a]pyrazine was obtained as a pink solid (2.77 g), sufficiently pure to be used in subsequent reactions.

후처리

  1. washwashed with saturated aqueous sodium hydrogen carbonate (2×50 ml) and brine (50 ml)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vaccuo

출처 및 근거

ORD 기록
ord-0fb4b0376bbf47478e875a3846773a01
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362018B2

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