Sulfuric Acid → 3-Phenoxy-5-(trifluoromethyl)picolinamide

HRID 1809598

반응식

HRID 1809598 반응식
[O:1]([C:8]1[C:9]([C:18]#[N:19])=[N:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)[OH:21].[OH-].[NH4+]>>[O:1]([C:8]1[C:9]([C:18]([NH2:19])=[O:21])=[N:10][CH:11]=[C:12]([C:14]([F:17])([F:15])[F:16])[CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 674852863-Phenoxy-5-(trifluoromethyl)picolinonitrile

생성물 1

HCID 674866453-Phenoxy-5-(trifluoromethyl)picolinamide수율 84.3%

실험 절차

3-Phenoxy-5-(trifluoromethyl)picolinonitrile (0.190 g, 0.719 mmol) was combined with 2 ml of sulfuric acid and agitated for 3 hours. Ice was added to the mixture, and the solution was basified with ammonium hydroxide solution. The resulting slurry was filtered and solids washed with water and dried in the air to afford 3-phenoxy-5-(trifluoromethyl)picolinamide (0.171 g, 84.3% yield) as a white solid.

후처리

  1. additionIce was added to the mixture
  2. filtrationThe resulting slurry was filtered
  3. washsolids washed with water
  4. customdried in the air

출처 및 근거

ORD 기록
ord-370172ece5634327b70de642dfe49b82
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362037B2

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