Sodium Hydroxide → 3-Amino-1-(thiophen-3-yl)propan-1-ol

HRID 1809674노트

반응식

HRID 1809674 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[O:7]=[C:8]([C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)[CH2:9][C:10]#[N:11].[OH-].[Na+]>C1COCC1>[NH2:11][CH2:10][CH2:9][CH:8]([C:12]1[CH:16]=[CH:15][S:14][CH:13]=1)[OH:7]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 27400753-Oxo-3-(thiophen-3-yl)propanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 651850053-Amino-1-(thiophen-3-yl)propan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
25 °C

실험 절차

To a stirred suspension of LAH (1.45 g, 38.1 mmol) in dry THF (120 mL) was added a solution of 3-oxo-3-(thiophen-3-yl)propanenitrile (4.8 g, 31.8 mmol) in dry THF (40 mL) dropwise at 0° C. under nitrogen atmosphere. The mixture was warmed to 25° C. and then heated at 65° C. for 6 hours. After cooling to 0° C., a saturated solution of sodium hydroxide (2 mL) was added dropwise and the mixture was filtered. The filtrate was concentrated to dryness to give crude 3-amino-1-thiophen-3-yl-propan-1-ol which was used in next step without further purification.

후처리

  1. temperatureheated at 65° C. for 6 hours
  2. temperatureAfter cooling to 0° C.
  3. filtrationthe mixture was filtered
  4. concentrationThe filtrate was concentrated to dryness

출처 및 근거

ORD 기록
ord-349e82b266b44e12810cfc41df88d149
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362023B2

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