Hydrochloric Acid → HCID 178511334, 화합물

HRID 1809762노트

반응식

HRID 1809762 반응식
C(OC(=O)[NH:7][CH2:8][CH:9]([C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[CH:36]=1)[NH:10][C:11]1[N:16]=[C:15]([C:17]2[C:25]3[C:20](=[N:21][C:22]([NH:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)=[N:23][CH:24]=3)[NH:19][N:18]=2)[CH:14]=[CH:13][N:12]=1)(C)(C)C.Cl>CCO>[Cl:41][C:37]1[CH:36]=[C:35]([CH:9]([NH:10][C:11]2[N:16]=[C:15]([C:17]3[C:25]4[C:20](=[N:21][C:22]([NH:26][CH2:27][CH2:28][N:29]5[CH2:30][CH2:31][O:32][CH2:33][CH2:34]5)=[N:23][CH:24]=4)[NH:19][N:18]=3)[CH:14]=[CH:13][N:12]=2)[CH2:8][NH2:7])[CH:40]=[CH:39][CH:38]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178453678HCID 178453678, 화합물

생성물 1

HCID 178511334HCID 178511334, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

(2-(3-Chloro-phenyl)-2-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-ylamino}-ethyl)-carbamic acid tert-butyl ester (100 mg, 0.17 mmol) was dissolved in EtOH (4 mL), then HCl (4 mL) was added. The reaction mixture was stirred at room temperature for 10 hours. The solvent was removed under reduced pressure to afford the crude product which was purified by prep-HPLC to afford 1-(3-chloro-phenyl)-N1-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-yl}-ethane-1,2-diamine; hydrochloride. (Yield 24 mg, 23.7%).

후처리

  1. customThe solvent was removed under reduced pressure
  2. customto afford the crude product which
  3. customwas purified by prep-HPLC

출처 및 근거

ORD 기록
ord-89dd80a6721d4ae7980456cd34654d6a
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362023B2

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