Hydrochloric Acid → HCID 178478112, 화합물

HRID 1809779노트

반응식

HRID 1809779 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]3[NH:21][N:22]=[C:23]([C:24]4[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][C:32]5[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[CH:33]=5)[N:25]=4)[C:18]3=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCO>[Cl:38][C:34]1[CH:33]=[C:32]([CH:37]=[CH:36][CH:35]=1)[CH2:31][NH:30][C:26]1[N:25]=[C:24]([C:23]2[C:18]3[C:19](=[N:20][C:15]([NH:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[N:16][CH:17]=3)[NH:21][N:22]=2)[CH:29]=[CH:28][N:27]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178452083HCID 178452083, 화합물

생성물 1

HCID 178478112HCID 178478112, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 4-{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-piperidine-1-carboxylic acid tert-butyl ester (80 mg, 0.15 mmol) in EtOH (4 mL) was added conc. HCl (4 mL). The reaction mixture was stirred at room temperature for 15 hours. The solvent was then removed and the residue was purified by prep-HPLC to afford {3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-yl-amine; hydrochloride. (Yield 20 mg, 26.3%).

후처리

  1. customThe solvent was then removed
  2. customthe residue was purified by prep-HPLC

출처 및 근거

ORD 기록
ord-8fc61330bcf141359db1db101175c8e7
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362023B2

반응 노트

불러오는 중…