Acetonitrile → 1-[2-Bromo-5-(trifluoromethyl)phenyl]ethan-1-one

HRID 1810266노트

반응식

HRID 1810266 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[CH:12]([OH:14])[CH3:13].C[N+]1([O-])CCOCC1.CC#N>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:11])[F:9])=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13]

참가 물질

6

반응물 3

HCID 6342AcetonitrileHCID 82029Methyl morpholine oxideHCID 574587951-(2-Bromo-5-(trifluoromethyl)phenyl)ethanol

생성물 1

HCID 574587961-[2-Bromo-5-(trifluoromethyl)phenyl]ethan-1-one

시약·촉매·용매 2

HCID 178419074HCID 178419074, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

1-(2-Bromo-5-trifluoromethyl-phenyl)-ethanol (0.914 g, 3.40 mmol), N-methylmorpholine N-oxide (0331 g, 6.24 mmol), and tetrapropylammonium perruthenate (0.109 g, 0.31 mmol) were combined in CH2Cl2 (18 mL) and MeCN (0.9 mL) and stirred at room temperature for 30 minutes. Once no starting material was seen by analytical LCMS, the mixture was filtered through Celite and purified by silica gel chromatography (0-100% EtOAc in hexanes) to give the title compound.

후처리

  1. filtrationthe mixture was filtered through Celite
  2. custompurified by silica gel chromatography (0-100% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-d645f9ba546e40b7870fb2ebd1abf851
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362044B2

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