Hydrochloric Acid → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

HRID 1810309노트

반응식

HRID 1810309 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:19][C:20]([OH:22])=[O:21])[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:24]O>O1CCOCC1>[CH3:24][O:21][C:20](=[O:22])[CH2:19][C:11]1[CH:12]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 59644613(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

생성물 1

HCID 58149337(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
80 °C

실험 절차

To a solution of (3-benzyloxy-5-trifluoromethyl-phenyl)-acetic acid (1.5 g, 4.8 mmol) in MeOH (10 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 80° C. for 1 hour. The mixture was concentrated and purified by silica gel chromatography to give the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-f682cdeaf7f448dfb8998b6cbbfcf36c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362044B2

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