Sodium Hydroxide → 2-(3-Bromo-5-chlorophenyl)acetic acid

HRID 1810441노트

반응식

HRID 1810441 반응식
C[O:2][C:3](=[O:17])[CH:4]([C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Br:16])[CH:10]=1)C(OC)=O.[OH-].[Na+]>CO>[Br:16][C:11]1[CH:10]=[C:9]([CH2:4][C:3]([OH:17])=[O:2])[CH:14]=[C:13]([Cl:15])[CH:12]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 574588062-(3-Bromo-5-chloro-phenyl)-malonic acid dimethyl ester

생성물 1

HCID 153652222-(3-Bromo-5-chlorophenyl)acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-(3-Bromo-5-chloro-phenyl)-malonic acid dimethyl ester (19 g, 59 mmol) in MeOH (500 mL) was treated with 1N aqueous NaOH (237 mL, 237 mmol) at 50° C. for 1.5 hours. The mixture was concentrated, and the residue was acidified and extracted twice with EtOAc. The combined organic layers were dried, filtered, and concentrated to give the title compound.

후처리

  1. concentrationThe mixture was concentrated
  2. extractionextracted twice with EtOAc
  3. customThe combined organic layers were dried
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-41b759f1484f40c1a41284429219fd41
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362044B2

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