Water → 1-Benzylimidazolidin-2-one

HRID 1811045

반응식

HRID 1811045 반응식
[NH:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6].[H-].[Na+].Br[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.O>CN(C=O)C>[CH2:10]([N:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 84532-ImidazolidinoneHCID 24758Sodium hydride

생성물 1

HCID 2314031-Benzylimidazolidin-2-one수율 16%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Step 1 A solution of imidazolidin-2-one (500 mg, 5.81 mmol) in DMF (30 mL) was stirred on ice and treated with sodium hydride, 60% oil dispersion (264 mg, 6.60 mmol). The mixture was stirred at rt for 50 min, then was treated with (bromomethyl)benzene (0.691 mL, 5.81 mmol). After 2 h, the mixture was poured into water and extracted three times with EtOAc. The combined organic layers were dried and concentrated, and the residue was purified by column chromatography (eluting with EtOAc) to provide 1-benzylimidazolidin-2-one as a white solid (160 mg, 16%). 1H NMR (400 MHz, chloroform-d) δ 7.22-7.39 (5 H, m), 4.53 (1 H, br. s.), 4.37 (2 H, s), 3.25-3.46 (4 H, m).

후처리

  1. waitAfter 2 h
  2. extractionextracted three times with EtOAc
  3. customThe combined organic layers were dried
  4. concentrationconcentrated
  5. customthe residue was purified by column chromatography (eluting with EtOAc)

출처 및 근거

ORD 기록
ord-54add59c9343403ca4fe325f0276d458
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08362065B2

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