Formamide → HCID 135957237, 화합물
반응식
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]2[S:6](=[O:10])(=[O:9])[CH2:7][CH2:8][C:4]=2[C:3]=1[C:13]([OH:15])=O.[CH:16]([NH2:18])=O.O>CN(C)C=O>[O:9]=[S:6]1(=[O:10])[C:5]2=[CH:11][CH:12]=[C:2]3[C:3]([C:13](=[O:15])[NH:18][CH:16]=[N:1]3)=[C:4]2[CH2:8][CH2:7]1참가 물질
5
실험 절차
0.87 g (3.83 mmol) of 5-amino-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]-thiophene-4-carboxylic acid was suspended in 2.0 ml of N,N-dimethyl-formamide and, after addition of 0.76 ml (19.14 mmol) of formamide, reacted in a microwave at 150° C. and 60 W for 40 min. During the reaction, the pressure in the microwave rose to 20 bar. The reaction mixture was then added to water. The precipitated solid was filtered off with suction and washed successively with water and diethyl ether and dried in vacuo overnight. 440 mg of the desired compound were obtained.
후처리
- customreacted in a microwave at 150° C.
- customDuring the reaction
- filtrationThe precipitated solid was filtered off with suction
- washwashed successively with water and diethyl ether
- customdried in vacuo overnight
출처 및 근거
- ORD 기록
- ord-cececc1be3b44a75bbe302f258543598
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741333B2
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