5-Nitro-2-oxindole → 5-Amino-2-oxindole

HRID 18123

반응식

HRID 18123 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)([O-])=O>CC(N(C)C)=O.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2

참가 물질

4

반응물 1

HCID 2303665-Nitro-2-oxindole

생성물 1

HCID 27732135-Amino-2-oxindole수율 50.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 31374Dimethylacetamide용매

실험 절차

To a solution of 5-nitro-oxindole (25 g) in 120 mL of dimethylacetamide in a Parr bottle was added 10% Pd/C (0.5 g). The mixture was hydrogenated (40 psi H2) for 16 h. The catalyst was removed by filtration and the filtrate was diluted with ether (2 L) to provide 5-amino-oxindole (10.5 g; 50%).

후처리

  1. customfor 16 h
  2. customThe catalyst was removed by filtration
  3. additionthe filtrate was diluted with ether (2 L)

출처 및 근거

ORD 기록
ord-c74a7df036034b16a9d90a9fbaa46b63
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741336B2

연결된 노트

불러오는 중…