Anisole → 2-(4-chlorophenyl)-1-(4-methoxyphenyl)ethanone

반응식

[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17](O)=[O:18])=[CH:12][CH:11]=1.FC(F)(F)C(OC(=O)C(F)(F)F)=O>>[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]([C:4]2[CH:5]=[CH:6][C:1]([O:7][CH3:8])=[CH:2][CH:3]=2)=[O:18])=[CH:12][CH:11]=1

참가 물질

반응물 3

HCID 7519Anisole

HCID 9845Trifluoroacetic anhydride

HCID 15880(4-Chlorophenyl)acetic acid

생성물 1

HCID 4572422-(4-chlorophenyl)-1-(4-methoxyphenyl)ethanone

실험 절차

Anisole (13.9 g, 0.13 mol) is added to a stirred solution of 4-chlorophenylacetic acid (20.0 g, 0.12 mol) in trifluoroacetic anhydride (16.5 ml, 0.12 mol). The mixture is stirred in room temperature for 24 h. Ice water is added and the crystallized product is collected on a sinter and washed with water. The product is recrystallized from ethanol. The yield is 20.4 g, 67%.