tert-Butanol → HCID 69731332, 화합물

HRID 1814369노트

반응식

HRID 1814369 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[CH2:10]1[O:13][C@H:11]1[CH3:12].CC(C)([O-])C.[K+].CC(O)(C)C>C1COCC1>[N:1]1([CH2:10][C@H:11]([CH3:12])[OH:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1

참가 물질

6

반응물 4

HCID 6386tert-ButanolHCID 92211H-IndazoleHCID 146262(2S)-2-MethyloxiraneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 69731332HCID 69731332, 화합물수율 67%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 0.5 g (4.23 mmol) indazole, 0.3 mL (S)-propylene oxide (4.4 mmol), 0.53 g potassium t-butoxide (4.3 mmol) and 15 mL of 25:1 t-BuOH:THF was stirred in a sealed tube at 70° C. overnite. The solvent was removed in vacuo, 50 mL ethyl acetate was added to the residue, the mixture was filtered, concentrated and the residue purified by chromatography over silica eluting with 1:1 EtOAc:hexanes to yield 0.250 g (1.42 mmol, 67%) of the title compound as a viscous oil. MS (APCI) m/z 177 (M+1).

후처리

  1. customThe solvent was removed in vacuo, 50 mL ethyl acetate
  2. additionwas added to the residue
  3. filtrationthe mixture was filtered
  4. concentrationconcentrated
  5. customthe residue purified by chromatography over silica eluting with 1:1 EtOAc

출처 및 근거

ORD 기록
ord-c9e43ffe6ec548a49a6947d2df400bad
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06875765B2

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