Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1814694생성일: 2026년 10월 26일
Potassium trimethylsilanolate → 3-{3-(4-tert-Butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid
https://huagongshe.com/reaction/1814694
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium trimethylsilanolate | HCID 23668039 | — |
| 반응물 | 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester | HCID 53870922 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-{3-(4-tert-Butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid | HCID 22501965 | — |
반응 단계
To the above resin bound 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester was added a solution of potassium trimethylsilanolate in THF (1M, 5 mL). The mixture was shaken 4 hours at 25° C., filtered and allowed to react with a solution of acetic acid in THF (20%, 5 mL) at 25° C. overnight. Filtration followed by washing of the resin with dichloromethane (2×10 mL) afforded the resin bound title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06875760B2 |
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| 출처 데이터셋 | uspto-grants-2005_04 |
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| ORD ID | ord-c3a8b73efd144a8f83ce6fc5f30ab49a |
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| 출처 메모 | uspto-grants-2005_04 |
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