HRID1814694

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23668039

Potassium trimethylsilanolate

C3H9KOSi

结构：COC(=O)c1cccc(NC(=O)N(Cc2ccc(C(=O)Nc3nn[nH]n3)cc2)c2ccc(C(C)(C)C)cc2)c1

HCID53870922

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1ccc(N(Cc2ccc(C(=O)Nc3nn[nH]n3)cc2)C(=O)Nc2cccc(C(=O)O)c2)cc1

HCID22501965

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 25 °C

PROCEDURE

实验过程

To the above resin bound 3-{3-(4-tert-butylphenyl)-3-[4-(2H-tetrazol-5-ylcarbamoyl)benzyl]ureido}benzoic acid methyl ester was added a solution of potassium trimethylsilanolate in THF (1M, 5 mL). The mixture was shaken 4 hours at 25° C., filtered and allowed to react with a solution of acetic acid in THF (20%, 5 mL) at 25° C. overnight. Filtration followed by washing of the resin with dichloromethane (2×10 mL) afforded the resin bound title compound.

WORKUP

后处理

filtrationfiltered
customto react with a solution of acetic acid in THF (20%, 5 mL) at 25° C. overnight
filtrationFiltration
washby washing of the resin with dichloromethane (2×10 mL)
customafforded the resin

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c3a8b73efd144a8f83ce6fc5f30ab49a
来源数据集: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06875760B2
来源说明: uspto-grants-2005_04

反应 SMILES

C[O:2][C:3](=[O:39])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11]([N:13]([C:29]2[CH:34]=[CH:33][C:32]([C:35]([CH3:38])([CH3:37])[CH3:36])=[CH:31][CH:30]=2)[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:28])[NH:22][C:23]3[N:24]=[N:25][NH:26][N:27]=3)=[CH:17][CH:16]=2)=[O:12])[CH:5]=1.C[Si](C)(C)[O-].[K+]>C1COCC1>[C:35]([C:32]1[CH:31]=[CH:30][C:29]([N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:28])[NH:22][C:23]3[N:24]=[N:25][NH:26][N:27]=3)=[CH:17][CH:16]=2)[C:11](=[O:12])[NH:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:39])=[O:2])=[CH:34][CH:33]=1)([CH3:38])([CH3:36])[CH3:37]