Hydrochloric Acid → 2-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)

HRID 1814740노트

반응식

HRID 1814740 반응식
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 10538259tert-Butyl [2-(morpholin-4-yl)-2-oxoethyl]carbamate

생성물 1

HCID 122918142-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)수율 76%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a stirred solution of the above (2-morpholin-4-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester (0.44 g, 1.8 mmol) in 1,4-dioxane (4.0 mL), HCl (4.0 mL of a 4 M solution in 1,4-dioxane) was added at room temperature. After one h, the precipitated product was collected via filtration and washed with EtOAc. The solid was dried under high vacuum to give 0.23 g (76%) of 2-amino-1-morpholin-4-yl-ethanone hydrochloride which was used without further purification.

후처리

  1. filtrationAfter one h, the precipitated product was collected via filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under high vacuum

출처 및 근거

ORD 기록
ord-83fba8d2fdac469082f67417fadf52a3
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878706B1

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