1-Carbethoxy-4-ethylamino-3-methylpiperidine → 4-Ethylamino-3-methylpiperidine

HRID 1814856노트

반응식

HRID 1814856 반응식
C([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][CH2:13][CH3:14])[CH:8]([CH3:15])[CH2:7]1)(OCC)=O>[OH-].[Na+]>[CH2:13]([NH:12][CH:9]1[CH2:10][CH2:11][NH:6][CH2:7][CH:8]1[CH3:15])[CH3:14]

참가 물질

3

반응물 1

HCID 222789001-Carbethoxy-4-ethylamino-3-methylpiperidine

생성물 1

HCID 222788594-Ethylamino-3-methylpiperidine

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
110 °C

실험 절차

1-Carbethoxy-4-ethylamino-3-methylpiperidine (2.3 g, 10.74 mmol) was suspended in 5 M NaOH solution (15 ml), stirred at 110° C. for 120 hr, cooled, extracted with ethyl acetate, dried (Na2SO4) and concentrated to dryness to afford 4-ethylamino-3-methylpiperidine. Yield 0.7 g (46%), C8H18N2, m/z 143, (M+1).

후처리

  1. temperaturecooled
  2. extractionextracted with ethyl acetate
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-7c81572937964c84ad9ea0cf4f9f1b4a
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878713B2

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