N-[4-(4-amino-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl]acetamide → 1-(4-aminobutyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine
반응식
[NH2:1][C:2]1[C:7]2[N:8]=[CH:9][N:10]([CH2:11][CH2:12][CH2:13][CH2:14][NH:15]C(=O)C)[C:6]=2[C:5]([CH3:19])=[C:4]([CH3:20])[N:3]=1>Cl>[NH2:15][CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[C:6]2[C:5]([CH3:19])=[C:4]([CH3:20])[N:3]=[C:2]([NH2:1])[C:7]=2[N:8]=[CH:9]1참가 물질
3
반응 조건
- 온도
- 100 °C
실험 절차
A solution of N-[4-(4-amino-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl]acetamide (˜2.1 g) in 6 N hydrochloric acid (30 mL) was sealed in a flask and then heated at 100° C. for about 30 hours. The reaction mixture was allowed to cool to ambient temperature and then filtered to remove any particulates. The filtrate was made basic (pH 14) with 25% sodium hydroxide and then extracted with chloroform (×2). The aqueous layer was combined with sodium chloride (20 g) and then extracted with chloroform (×3). The organics were combined, washed with brine, dried over sodium sulfate and then concentrated under reduced pressure to provide 1.44 g of 1-(4-aminobutyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine.