Hydrochloric Acid → HCID 68984012, 화합물

HRID 1815505노트

반응식

HRID 1815505 반응식
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:7]=[CH:6][C:3]=1[CH:4]=O.C(O)(=O)[CH2:21][C:22]([OH:24])=[O:23].N1CCCCC1.Cl>N1C=CC=CC=1>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:7]=[CH:6][C:3]=1[CH:4]=[CH:21][C:22]([OH:24])=[O:23]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 11088283HCID 11088283, 화합물

생성물 1

HCID 68984012HCID 68984012, 화합물수율 75.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 2,3-dichloro-4-(2-methoxyphenylthio)-benzaldehyde (2.03 g), 1.44 g malonic acid, 5 mL pyridine, and 0.100 g piperidine was heated to 115 degrees for 1.5 hours. The mixture was cooled, and ice and HCl were added. The resulting solid was: filtered, washed with water and dissolved in tetrahydrofuran. This solution was dried over sodium sulfate, the solvent removed and ether added to give 1.733 g of product, m.p. 187-188 C.

후처리

  1. temperaturewas heated to 115 degrees for 1.5 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. washwashed with water
  5. dissolutiondissolved in tetrahydrofuran
  6. dry with materialThis solution was dried over sodium sulfate
  7. customthe solvent removed
  8. additionether added

출처 및 근거

ORD 기록
ord-e7c4077b4bc948b6840d079a7747a91a
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06878700B1

반응 노트

불러오는 중…