Methylamine → 6H-oxazolo[4,5-e]indole

HRID 18158

반응식

HRID 18158 반응식
[CH3:1][NH2:2].[OH:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[CH:7]2>CN(C=O)C.O=[Mn]=O>[N:2]1[C:5]2=[C:6]3[C:10](=[CH:11][CH:12]=[C:4]2[O:3][CH:1]=1)[NH:9][CH:8]=[CH:7]3

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 160545-Hydroxyindole

생성물 1

HCID 113326096H-oxazolo[4,5-e]indole

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6228Dimethylformamide용매

실험 절차

0.5 mmol of methylamine and 4.13 mmol of MnO2 are added to a solution of 0.4 mmol of 5-hydroxy-1H-indole in 3 ml of DMF, and the mixture is stirred at room temperature for 18 hours. The suspension is filtered through Celite and subjected to conventional work-up, giving 6H-oxazolo[4,5-e]indole; ESI 159.

후처리

  1. filtrationThe suspension is filtered through Celite

출처 및 근거

ORD 기록
ord-48e2ebd3ce31455ea6dd59c9383f0a06
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741343B2

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