Nadide (JAN/USAN/INN) → Propan-2-yl 4-bromo-3-hydroxybutanoate

HRID 1816192

반응식

HRID 1816192 반응식
P(O)(O)([O-])=O.[K+].P(O)([O-])([O-])=O.[K+].[K+].C1C=[N+]([C@@H]2O[C@H](COP(OP(OC[C@H]3O[C@@H](N4C5N=CN=C(N)C=5N=C4)[C@H](O)[C@@H]3O)(O)=O)(O)=O)[C@@H](O)[C@H]2O)C=C(C(N)=O)C=1.CCCCCCCCCC.[Br:68][CH2:69][C:70](=[O:78])[CH2:71][C:72]([O:74][CH:75]([CH3:77])[CH3:76])=[O:73]>CC(O)C>[Br:68][CH2:69][CH:70]([OH:78])[CH2:71][C:72]([O:74][CH:75]([CH3:76])[CH3:77])=[O:73]

참가 물질

6

반응물 4

HCID 5893Nadide (JAN/USAN/INN)HCID 15600DecaneHCID 11075004Isopropyl 4-bromo-3-oxobutanoateHCID 21889592Monopotassium phosphate dipotassium phosphate

생성물 1

HCID 22492795Propan-2-yl 4-bromo-3-hydroxybutanoate

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To 50 ml of 50 mM monopotassium phosphate-dipotassium phosphate buffer (pH 7.0) containing 5% of 2-propanol were added 0.1 mmol of NAD+ and 6 g of the washed cells described above. To this mixture was added 50 ml of decane containing 70 mg (0.31 mmol) of isopropyl 4-bromo-3-oxobutanoate, and the mixture was stirred at room temperature for a night and day. Celite was then put into the reaction solution, and stirred for a while and filtered off to separate the resultant solution. The aqueous layer was further extracted three times with ethyl acetate, and combined organic layers were concentrated to give 50 mg of isopropyl 4-bromo-3-hydroxybutanoate.

후처리

  1. stirringstirred for a while
  2. filtrationfiltered off
  3. customto separate the resultant solution
  4. extractionThe aqueous layer was further extracted three times with ethyl acetate
  5. concentrationwere concentrated

출처 및 근거

ORD 기록
ord-dd56711786f74bf99ae0757b88d9cd15
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884607B2

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