Pyrrolidine → HCID 22493262, 화합물

HRID 1816267노트

반응식

HRID 1816267 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.CC1C=CC2C(=O)OC(=O)[NH:29]C=2C=1>>[NH:16]1[CH2:20][CH2:19][N:29]=[C:17]1[CH2:18][NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10]

참가 물질

4

반응물 3

HCID 31268PyrrolidineHCID 124257907-Methyl-2H-3,1-benzoxazine-2,4(1H)-dioneHCID 22493261HCID 22493261, 화합물

생성물 1

HCID 22493262HCID 22493262, 화합물

실험 절차

(2-Amino-4-methylphenyl)(1-pyrrolidinyl)methanone (prepared from pyrrolidine and 7-methyl-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give {2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-4-methylphenyl}(1-pyrrolidinyl)methanone.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-54fd6da14c8947848984429aee6dbaba
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884801B1

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