Methyl iodide → (2,3-Dimethoxyphenyl)(phenyl)methanone

반응식

CO[C:3]1[CH:8]=[C:7]([OH:9])[C:6]([C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])=[CH:5][C:4]=1S(O)(=O)=O.I[CH3:23].[C:24](=[O:27])([O-])[O-].[K+].[K+]>>[CH3:24][O:27][C:8]1[C:7]([O:9][CH3:23])=[C:6]([CH:5]=[CH:4][CH:3]=1)[C:10]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11]

참가 물질

반응물 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 19988Sulisobenzone

생성물 1

HCID 13270875(2,3-Dimethoxyphenyl)(phenyl)methanone

실험 절차

In Scheme II, benzophenone 4 was treated with iodomethane in the presence of potassium carbonate to produce the dimethoxy-benzophenone 7. Bromination of 7 with bromine in chloroform furnished bromo-benzophenone 8, which was converted to benizisoxazole 9 according to Scheme I.

출처 및 근거

ORD 기록: ord-103c406b5aa941edb3000b629ec4d5b6
출처 데이터셋: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06884814B2

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