Hydrochloric Acid → HCID 11298899, 화합물

HRID 1816541노트

반응식

HRID 1816541 반응식
[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([N+:13]([O-])=O)[CH:4]=1)#[N:2].[H][H].[ClH:18]>O.[OH-].[Pd+2].[OH-]>[Cl-:18].[NH2:13][C:5]1[CH:4]=[C:3]([CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])[CH2:1][NH3+:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 11356202Methyl 4-cyano-2-nitrobenzoateHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 11298899HCID 11298899, 화합물

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 962Water용매

실험 절차

18.5 g (0.09 mol) of methyl 4-cyano-2-nitrobenzoate and 0.93 g of palladium hydroxide (20% on charcoal) are suspended in a mixture of 8 ml of concentated hydrochloric acid (30% strength) and 315 ml of water in a Hastelloy stirred autoclave. Then, the mixture is hydrogenated at a hydrogen pressure of 17 bar until the hydrogen uptake is complete. After the pressure in the autoclave has been released and the catalyst filtered off, the filtrate is evaporated completely. This gives 19.5 g (97% strength) of 3-amino-4-methoxycarbonylbenzylammonium chloride of melting point 200-205° C.

후처리

  1. filtrationthe catalyst filtered off
  2. customthe filtrate is evaporated completely

출처 및 근거

ORD 기록
ord-8b9938f7bc724cc58503b964bc32793e
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884903B2

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