Acetone → 2-Hydroxy-4-(trifluoromethyl)benzaldehyde

반응식

COC[C:4]1([CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH2:7]1)C=O.Cl.[OH2:17].C[C:19](C)=[O:20]>>[OH:17][C:4]1[CH:7]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:9]=[CH:10][C:11]=1[CH:19]=[O:20]

참가 물질

반응물 4

HCID 180Acetone

HCID 313Hydrochloric Acid

HCID 962Water

HCID 22494069HCID 22494069, 화합물

생성물 1

HCID 224939012-Hydroxy-4-(trifluoromethyl)benzaldehyde

실험 절차

5.0 g of 1-(methoxymethyl)-3-(trifluoromethyl)benzaldehyde was dissolved in 25 ml acetone, and 22 ml of 6 N hydrochloric acid was added. The mixture was reacted at room temperature for 3 hours, and water was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evapaorated, to give 4.5 g of 2-hydroxy-4-(trifluoromethyl)benzaldehyde as a pale reddish orange oil.