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Iodoethane → HCID 22494032, 화합물

HRID 1816603
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HRID 1816603 반응식
C([C:3]([O:24][CH:25]([CH3:27])[CH3:26])([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:9]=1)[C:4]([OH:6])=[O:5])C.I[CH2:29][CH3:30].C(=O)([O-])[O-].[K+].[K+].[C:37](OCC)(=O)[CH3:38]>CN(C)C=O>[C:20]([O:19][C:17]([NH:16][CH2:15][C:10]1[CH:9]=[C:8]([CH2:7][CH:3]([O:24][CH:25]([CH3:26])[CH3:27])[C:4]([O:6][CH2:29][CH3:30])=[O:5])[CH:13]=[CH:12][C:11]=1[O:14][CH2:37][CH3:38])=[O:18])([CH3:22])([CH3:23])[CH3:21]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6340IodoethaneHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 22494120HCID 22494120, 화합물

생성물 1

HCID 22494032HCID 22494032, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
50 °C

실험 절차

795 mg of ethyl 3-(3-[(tertiary butoxycarbonyl)amino]methyl-4-hydroxyphenyl)-2-isopropoxypropionic acid was dissolved in 2 ml N,N-dimethylformamide, and 0.3 ml iodoethane and 200 mg potassium carbonate were successively added. After stirring at 50° C. for 4 hours, the reaction mixture was diluted with ethyl acetate, The organic layer was washed with water and brine, dried over anhydrous magnesium sulfate and the solvent was evapoarated. The residue was purified by silica gel column chromatography, and from fractions eluted with hexane-ethyl acetate (8:1), 185 mg of ethyl 3-(3-[(tertiary butoxycarbonyl)amino]methyl-4-ethoxyphenyl)-2-isopropoxypropionate was obtained.

후처리

  1. washThe organic layer was washed with water and brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe residue was purified by silica gel column chromatography
  4. washfrom fractions eluted with hexane-ethyl acetate (8:1)

출처 및 근거

ORD 기록
ord-31a33ce103bd4d1dbb78675bfc4e0214
출처 데이터셋
uspto-grants-2005_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06884821B1

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