Sodium Hydroxide → 1-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

HRID 1816741노트

반응식

HRID 1816741 반응식
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][C:19]([O:28][CH3:29])([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)C>[CH3:29][O:28][C:19]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:18][CH2:17][N:16]([C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)=[CH:15][CH:14]=2)[CH2:21][CH2:20]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 224947141-Acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

생성물 1

HCID 224946521-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine수율 97.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.5 g) and 10% NaOH aq. (10.2 ml) in ethyl alcohol (50 ml) was refluxed for 23.5 hours. The reaction mixture was evaporated under reduced pressure. The residue was washed with water, and dried to give 1-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.18 g).

후처리

  1. temperaturewas refluxed for 23.5 hours
  2. customThe reaction mixture was evaporated under reduced pressure
  3. washThe residue was washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-817354e23e2d4fe7b375eb987f56526b
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884868B1

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