4-Bromophenol → 1-Bromo-4-(4-bromobutoxy)benzene

HRID 1816769노트

반응식

HRID 1816769 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Br:9][CH2:10][CH2:11][CH2:12][CH2:13]Br.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.C(OCC)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][CH2:12][CH2:11][CH2:10][Br:9])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 78084-BromophenolHCID 80561,4-DibromobutaneHCID 11430Potassium Carbonate

생성물 1

HCID 80633591-Bromo-4-(4-bromobutoxy)benzene

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 4-bromophenol (3 g) and 1,4-dibromobutane (6.2 ml) in N,N-dimethylformamide (30 ml) was treated with potassium carbonate (2.89 g) at room temperature for 27 hours. The mixture was diluted with ethyl acetate and washed with brine. The organic layer was dried over magnesium sulfate, filtered, and evaporated. The residue was purified by silica gel chromatography (25:1 hexane-ethyl acetate elution) to give 1-bromo-4-(4-bromobutoxy)benzene (3.09 g).

후처리

  1. washwashed with brine
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. filtrationfiltered
  4. customevaporated
  5. customThe residue was purified by silica gel chromatography (25:1 hexane-ethyl acetate elution)

출처 및 근거

ORD 기록
ord-f9fe90f1826b433a9035dd98e41faffc
출처 데이터셋
uspto-grants-2005_04
특허 번호
US06884868B1

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