Ammonium formate → 1-[4-[4-[4-(4-Methoxybutoxy)phenyl]piperidin-1-yl]phenyl]piperazine

온도

100 °C

To a mixture of 4-[4-[4-[4-(4-methoxybutoxy)phenyl]-3,6-dihydro-2H-pyridin-1-yl]phenyl]piperazine-1-carboxylic acid benzyl ester (2.20 g) and ammonium formate (1.25 g) in 90% methanol (44 ml) and dioxane was added 10% palladium on carbon at room temperature. The reaction mixture was heated at 100° C. for 2 hours. After cooling, the reaction mixture was filtered and evaporated. Sodium hydrogen carbonate solution was added to the residue. And the resulting precipitate was collected by filtration, washed with water and dried under hi-vacuum to give 1-[4-[4-[4-(4-methoxybutoxy)phenyl]piperidin-1-yl]phenyl]piperazine (1.36 g).

1. temperatureAfter cooling
2. filtrationthe reaction mixture was filtered
3. customevaporated
4. additionSodium hydrogen carbonate solution was added to the residue
5. filtrationAnd the resulting precipitate was collected by filtration
6. washwashed with water
7. customdried under hi-vacuum

ORD 기록

ord-fbf4101dc8404ba9aa56b03d817d6072

출처 데이터셋

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06884868B1