Hydrochloric Acid → Methyl 6-(4-fluorobenzyl)-4-hydroxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

HRID 1817294노트

반응식

HRID 1817294 반응식
[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]=[CH:9][C:8]2=[O:13])=[CH:4][CH:3]=1.C[O:17][C:18]1O[C:21]([C:23]([O:25][CH3:26])=[O:24])=[N:20][CH:19]=1.Cl>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][C:10]3[C:21]([C:23]([O:25][CH3:26])=[O:24])=[N:20][CH:19]=[C:18]([OH:17])[C:9]=3[C:8]2=[O:13])=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 1491126Methyl 5-methoxy-1,3-oxazole-2-carboxylateHCID 690647451-(4-Fluorobenzyl)-5,6-dihydropyridin-2-(1H)-one

생성물 1

HCID 69062288Methyl 6-(4-fluorobenzyl)-4-hydroxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridine-1-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

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온도
120 °C

실험 절차

In a sealed tube, 1-(4-fluorobenzyl)-5,6-dihydropyridin-2-(1H)-one (3.84 g, 18.7 mmol), and methyl 5-methoxy-1,3-oxazole-2-carboxylate prepared in Step 5 (2.94 g, 18.7 mmol), were combined. The reaction mixture was heated at 120° C. After 24 hours, the resultant mixture was cooled and methanol saturated with HCl (2 mL) was added. The product mixture stirred at room temperature for 40 minutes, then was concentrated under vacuum. The residual crude material was diluted with DMSO (6.0 mL) and filtered to give the title compound.

후처리

  1. concentrationwas concentrated under vacuum
  2. additionThe residual crude material was diluted with DMSO (6.0 mL)
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-187951accfdc4634834b0c04bc955b82
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598264B2

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