1-Butanol → 1-(Glycyloxy)butane chloride

HRID 1817299

반응식

HRID 1817299 반응식
Cl.[NH2:2][CH2:3][C:4]([OH:6])=[O:5].S(Cl)([Cl:9])=O.[CH2:11](O)[CH2:12][CH2:13][CH3:14]>>[Cl-:9].[NH2:2][CH2:3][C:4]([O:6][CH2:11][CH2:12][CH2:13][CH3:14])=[O:5]

참가 물질

4

반응물 3

HCID 2631-ButanolHCID 22316Glycine HydrochlorideHCID 24386Thionyl Chloride

생성물 1

HCID 866139031-(Glycyloxy)butane chloride

반응 조건

온도
70 °C

실험 절차

To a suspension of glycine hydrochloride (10 g, 89.6 mmol) in 250 mL butanol under nitrogen was added thionyl chloride (45.7 mL, 627 mmol) dropwise. After the addition was complete, the solution was heated at 70° C. overnight. The volatile components were removed on the roto-evaporator and the residue was suspended and evaporated from toluene three times. The resulting crude gum was dissolved in an equal weight of toluene for easy transfer and was used as is in the next reaction.

후처리

  1. additionAfter the addition
  2. customThe volatile components were removed on the roto-evaporator
  3. customevaporated from toluene three times
  4. dissolutionThe resulting crude gum was dissolved in an equal weight of toluene for easy transfer
  5. customas is in the next reaction

출처 및 근거

ORD 기록
ord-491dd942da334ab9a9e0643ea6bc3180
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598264B2

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