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Isobutyl iodide → HCID 69065596, 화합물

HRID 1817508
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HRID 1817508 반응식
[Si:1]([O:18][C:19]1[CH:20]=[C:21]([C:25]([C:27]2[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[NH:29][N:28]=2)=[O:26])[CH:22]=[CH:23][CH:24]=1)([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].I[CH2:39][CH:40]([CH3:42])[CH3:41].CCCCCC.C(OCC)(=O)C>CN(C=O)C>[C:14]([Si:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[O:18][C:19]1[CH:20]=[C:21]([C:25]([C:27]2[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[N:29]([CH2:39][CH:40]([CH3:42])[CH3:41])[N:28]=2)=[O:26])[CH:22]=[CH:23][CH:24]=1)([CH3:16])([CH3:17])[CH3:15]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 10556Isobutyl iodideHCID 24758Sodium hydrideHCID 21226206Ethyl acetate hexaneHCID 69059931HCID 69059931, 화합물

생성물 1

HCID 69065596HCID 69065596, 화합물수율 87%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(3-{[tert-butyl(diphenyl)silyl]oxy}phenyl)(1H-indazol-3-yl)methanone (0.67 g, 0.0014 mol) was dissolved in DMF (10 mL). Sodium hydride (66%, 0.042 g, 0.0017 mol) was added, and the reaction was stirred until gas evolution stops. 1-iodo-2-methylpropane (0.242 mL, 0.0021 mol) was added. The reaction was stirred at room temperature overnight. The reaction is quenched with water and extracted with ethyl acetate. The desired product (0.650 g, 0.0012 mol, 87%) is isolated by chromatography with hexane/ethyl acetate (10:1).

후처리

  1. stirringThe reaction was stirred at room temperature overnight
  2. customThe reaction is quenched with water
  3. extractionextracted with ethyl acetate

출처 및 근거

ORD 기록
ord-7e6d3479a19e4267b633bb78f375a57d
출처 데이터셋
uspto-grants-2009_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07598286B2

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