3-Phenylprop-2-Enal → (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile

반응식

[CH:1](=O)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:11]([CH2:13][C:14]([N-:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])#[N:12]>>[CH2:17]([NH:16][C:14](/[C:13](=[CH:1]/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)/[C:11]#[N:12])=[O:15])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

반응물 2

HCID 3073-Phenylprop-2-Enal

HCID 178511179N-(cyanoacetyl)benzylamide

생성물 1

HCID 5835419(E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile

실험 절차

The compound was prepared as described in Example 3 by adding cinnamaldehyde (0.048 ml, 0.38 mmol) to N-(cyanoacetyl)benzylamide (Example 4, 0.066 g, 0.38 mmol). After refluxing for 1 h and recrystallization from ethanol a white solid was obtained (0.074 g, 68%). The product gave the following analytical data:

후처리

customThe compound was prepared
temperatureAfter refluxing for 1 h
customrecrystallization from ethanol a white solid
customwas obtained (0.074 g, 68%)
customThe product gave the following analytical data

출처 및 근거

ORD 기록: ord-fb621f5ddb954b20915cd77e7e8bdd97
출처 데이터셋: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07598419B2

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