HCID 57566815, 화합물 → 1-(3-Aminophenyl)-4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one

HRID 1819345노트

반응식

HRID 1819345 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:17]2[CH2:21][N:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=3)[C:19](=[O:31])[CH2:18]2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.CCO.[Ni]>[NH2:28][C:24]1[CH:23]=[C:22]([N:20]2[CH2:21][CH:17]([C:11]3[CH:12]=[CH:13][C:14]([O:15][CH3:16])=[C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH:10]=3)[CH2:18][C:19]2=[O:31])[CH:27]=[CH:26][CH:25]=1

참가 물질

4

반응물 1

HCID 57566815HCID 57566815, 화합물

생성물 1

HCID 99775741-(3-Aminophenyl)-4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one

시약·촉매·용매 2

HCID 935Nickel촉매HCID 21584252Ethanol ethylacetate용매

실험 절차

To a solution of 4-(3-benzyloxy-4-methoxyphenyl)-1-(3-nitrophenyl)-pyrrolidin-2-one (100 mg) in EtOAc/EtOH (2 mL, 1:1) was added Raney Ni. The mixture was then put under vacuum and recharged with H2. The mixture was stirred under H2 for 10 h. After filtration, concentration gave crude product.

후처리

  1. filtrationAfter filtration, concentration
  2. customgave crude product

출처 및 근거

ORD 기록
ord-a54e3dc4c3a44f6094ba24923ff67fb8
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601742B2

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