Hydrochloric Acid → HCID 178511549, 화합물

HRID 1819491노트

반응식

HRID 1819491 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[C:21]([N+:22]([O-:24])=[O:23])=[CH:20][N:19]=[C:18]([NH:25][CH:26]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[N:17]=2)[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][NH:15][C:16]2[C:21]([N+:22]([O-:24])=[O:23])=[CH:20][N:19]=[C:18]([NH:25][CH:26]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)[CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[N:17]=2)[CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59845663(4-{[2-(1,2-Diphenyl-ethylamino)-5-nitro-pyrimidin-4-ylamino]-methyl}-cyclohexyl)-carbamic acid tert-butyl ester

생성물 1

HCID 178511549HCID 178511549, 화합물수율 67.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

(4-{[2-(1,2-Diphenyl-ethylamino)-5-nitro-pyrimidin-4-ylamino]-methyl}-cyclohexyl)-carbamic acid tert-butyl ester (105 mg, 0.19 mmol) was dissolved in dioxane (5 mL). An HCl solution (2 mL of a 4M solution) was added. After 18 h, an oil separated from the solvent. The solvent was decanted and the oil was dissolved in water and lyopholized yielding 57 mg of the title compound as a pale yellow solid, m/z 447.3 [M+1]+.

후처리

  1. customan oil separated from the solvent
  2. customThe solvent was decanted
  3. dissolutionthe oil was dissolved in water

출처 및 근거

ORD 기록
ord-aa5959a3369242a0995f1ba46043a962
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07601714B2

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