Hydrochloric Acid → 1-[4-(5-Methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-piperazine hydrochloride

HRID 1820737노트

반응식

HRID 1820737 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:24]=[C:23]([CH3:25])[O:22][N:21]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[CH3:25][C:23]1[O:22][N:21]=[C:20]([C:17]2[CH:16]=[CH:15][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:19][CH:18]=2)[N:24]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 690377204-[4-(5-Methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 690366531-[4-(5-Methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-piperazine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1 mmol of 4-[4-(5-Methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester was stirred in 3 ml of 1,4-dioxane saturated with gaseous HCl. After 2 h at room temperature, the reaction mixture was evaporated to dryness to yield the title compound as a colorless solid. MS (m/e): 245.1 (MH+, 100%)

후처리

  1. customthe reaction mixture was evaporated to dryness

출처 및 근거

ORD 기록
ord-8bb86b2bf3634dcba2037a9b2dd7c5d2
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07605163B2

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