[2-(2-Chloro-4-nitrophenyl)ethyl]diethylamine → 3-Chloro-4-(2-diethylaminoethyl)phenylamine

HRID 1820864노트

반응식

HRID 1820864 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15]>C1COCC1.[H][H].[Ni]>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15]

참가 물질

5

반응물 1

HCID 68816908[2-(2-Chloro-4-nitrophenyl)ethyl]diethylamine

생성물 1

HCID 596916173-Chloro-4-(2-diethylaminoethyl)phenylamine

시약·촉매·용매 3

HCID 935Nickel촉매HCID 178418361HCID 178418361, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

2.00 g (7.79 mmol) of [2-(2-chloro-4-nitrophenyl)ethyl]diethylamine (VI.1.c) is dissolved in 50 mL of THF and hydrogenated for 2.5 hours at ambient temperature at a pressure of 25 psi with hydrogen and 0.8 g of Raney nickel as catalyst. Then the catalyst is filtered off and the solvent is eliminated. Yield: 1.80 g (100% of theory); Rf value: 0.45 (Alox, petroleum ether/ethyl acetate=1:1); C12H19ClN2; EII mass spectrum: m/z=227/229 [M+H]+.

후처리

  1. filtrationThen the catalyst is filtered off

출처 및 근거

ORD 기록
ord-d59303dc29e2476ea578ff554c76d8b5
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07605176B2

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