Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4-Dimethoxyphenylboronic acid → 8-[5-Methoxy-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4-Dimethoxyphenylboronic acid | HCID 2734702 | — |
| 반응물 | 3-Bromo-(1-phenylsulfonyl)indole | HCID 2776215 | — |
| 반응물 | 3-methylquinoline-8-sulfonyl Chloride | HCID 3574807 | — |
| 반응물 | 3-(Cyclopentyloxy)-4-methoxybenzeneboronic acid | HCID 4197993 | — |
| 반응물 | 1-Benzenesulfonyl-3-bromo-5-methoxy-indole | HCID 69006720 | — |
| 생성물 | 8-[5-Methoxy-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline | HCID 57891717 | — |
반응 단계
8-[5-Methoxy-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline 97 was prepared using the same protocol as described in Examples 21 and 22, substituting 8-quinoline-sulfonyl chloride, 1-Benzenesulfonyl-3-bromoindole and 3,4-dimethoxyphenyl boronic acid with 3-methyl-quinoline-8-sulfonyl chloride, 1-benzenesulfonyl-3-bromo-5-methoxy-indole and 3-cyclopentyloxy-4-methoxy-phenylboronic acid respectively. MS(ESI) [M+H+]+=543.20.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07605168B2 |
| 출처 데이터셋 | uspto-grants-2009_10 |
| ORD ID | ord-462bc5a6e366461baf663af8a2f94fb7 |
| 출처 메모 | uspto-grants-2009_10 |