Dimethyl Sulfoxide → 2-[(Benzothiazol-2-yl)carbonyl]-1-{N-[N-(tertbutyloxycarbonyl)-(L)-Alanyl]-glycyl}-(2S)-pyrrolidine
반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([OH:32])[C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16](=[O:31])[CH2:17][NH:18][C:19](=[O:30])[C@H:20]([CH3:29])[NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23].C(Cl)(=O)C(Cl)=O.CS(C)=O>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:16](=[O:31])[CH2:17][NH:18][C:19](=[O:30])[C@H:20]([CH3:29])[NH:21][C:22]([O:24][C:25]([CH3:26])([CH3:28])[CH3:27])=[O:23])=[O:32]참가 물질
4
실험 절차
40 (0.62 g, 0.134 mmol), oxalylchloride (0.207 ml, 2.41 mmol), DMSO (2.37 ml, 3.35 mmol), TEA (0.75 ml, 5.35 mmol)