hydroxylamine-O-sulfonic acid → 1,3-Benzenedicarbonitrile, 4-fluoro-
반응식
[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][C:3]=1[C:4]#[N:5].[NH2:12]OS(O)(=O)=O>O>[F:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]#[N:12])=[CH:6][C:3]=1[C:4]#[N:5]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of 2-fluoro-5-formylbenzonitrile (5.1 g, 33.9 mmol) in water (75 ml) was added hydroxylamine-O-sulphonic acid (4.6 g, 40.7 mmol) and the reaction mixture was heated at 50° C. for 5 h. The mixture was filtered and the solid material was washed with water and dried in vacuo for 18 h to give the title compound (4.3 g)
후처리
- filtrationThe mixture was filtered
- washthe solid material was washed with water
- customdried in vacuo for 18 h
출처 및 근거
- ORD 기록
- ord-cef91c3e4cb54f378394874c12c3c473
- 출처 데이터셋
- uspto-grants-2009_10
- 특허 번호
- US07608604B2
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