Phosphorus oxychloride → 1-Chloro-6-methoxy-3-methylisoquinoline

HRID 1821605

반응식

HRID 1821605 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=O)[NH:8][C:7]([CH3:14])=[CH:6]2.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:9]1[C:10]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2)[CH:6]=[C:7]([CH3:14])[N:8]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 123270606-Methoxy-3-methylisoquinolin-1(2H)-one

생성물 1

HCID 578930951-Chloro-6-methoxy-3-methylisoquinoline

실험 절차

Isoquinoline-1-one 43 was dissolved in POCl3 (2.5 mL) and heated at reflux for 1h. The excess POCl3 was removed in vacuo and the residue was dissolved in CHCl3. The resulting solution was washed with 1N aq. NaOH, water and saturated ag. NaCl. Evaporation of the solvent gave crude 44 which was used directly in the next step.

후처리

  1. temperatureheated
  2. temperatureat reflux for 1h
  3. customThe excess POCl3 was removed in vacuo
  4. dissolutionthe residue was dissolved in CHCl3
  5. washThe resulting solution was washed with 1N aq. NaOH, water and saturated ag
  6. customEvaporation of the solvent
  7. customgave crude 44 which

출처 및 근거

ORD 기록
ord-691bfe019da5468c974cab34905ed9b7
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07608592B2

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