Sodium Hydroxide → phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone

HRID 1821841노트

반응식

HRID 1821841 반응식
[C:1]1([C:7]([C:9]2[N:17](S(C3C=CC=CC=3)(=O)=O)[C:12]3=[CH:13][N:14]=[CH:15][CH:16]=[C:11]3[CH:10]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CCO>[C:1]1([C:7]([C:9]2[NH:17][C:12]3=[CH:13][N:14]=[CH:15][CH:16]=[C:11]3[CH:10]=2)=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 689825291h-Pyrrolo[2,3-c]pyridine,2-benzoyl-1-(phenylsulfonyl)-

생성물 1

HCID 57893467phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone수율 84.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Phenyl[1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methanone (Reference Example 13) (2.2 g, 6.1 mmol) and 10% aq NaOH (70 mL) in EtOH (135 mL) was heated to reflux. After 14 h, the mixture was concentrated under reduced pressure to remove most of the EtOH. The mixture was diluted with H2O (50 mL) and extracted with EtOAc (2×100 mL). The combined extracts were washed with saturated NaCl (25 mL), dried (Na2SO4) and concentrated under reduced pressure. Trituration in EtOAc/diethyl ether gave phenyl(1H-pyrrolo[2,3-c]pyridin-2-yl)methanone (1.14 g, 83%).

후처리

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customto remove most of the EtOH
  3. additionThe mixture was diluted with H2O (50 mL)
  4. extractionextracted with EtOAc (2×100 mL)
  5. washThe combined extracts were washed with saturated NaCl (25 mL)
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-eaaedbffbc1f4e0c9d736fc0419a3cf8
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07608627B2

반응 노트

불러오는 중…