Methyl L-phenylalaninate hydrochloride → HCID 53816216, 화합물

HRID 1822605노트

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HRID 1822605 반응식
[Cl:1][CH:2]1[C:10](Cl)([OH:11])[CH:9]=[CH:8][C:4]([C:5]([OH:7])=O)=[C:3]1[OH:13].[ClH:14].[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH2:19].CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.C(N(CC)CC)C>[CH3:15][O:16][C:17](=[O:27])[C@H:18]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:19][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([Cl:14])[C:10]([OH:11])=[C:2]([Cl:1])[C:3]=1[OH:13]

참가 물질

7

반응물 4

HCID 75736Methyl L-phenylalaninate hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69621019HCID 69621019, 화합물

생성물 1

HCID 53816216HCID 53816216, 화합물수율 63.1%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

To a solution of 3,4-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, (Step 5) to give the title compound (18.32 g, yield 57%).

후처리

  1. additionThen, the mixture was post-treated in the same manner as in the above Example 1, (Step 5)

출처 및 근거

ORD 기록
ord-a7e1308cf54448cca57929d0b63ed123
출처 데이터셋
uspto-grants-2006_05
특허 번호
USRE039088E1

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