Ethanol → HCID 22170132, 화합물

HRID 1823271노트

반응식

HRID 1823271 반응식
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[F:18])=[N:8][O:9][C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+].C(O)C>O1CCCC1>[F:18][C:13]1[CH:14]=[N:15][CH:16]=[CH:17][C:12]=1[C:7]1[C:6]([C:4]([OH:5])=[O:3])=[C:10]([CH3:11])[O:9][N:8]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 57425437Ethyl 3-(3-Fluoro-4-pyridyl)-5-methylisoxazole-4-carboxylate

생성물 1

HCID 22170132HCID 22170132, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Combine 3-(3-fluoro-pyridin-4-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (2.00 g, 0.008 mol) with aqueous sodium hydroxide (2N, 15.0 mL, 0.03 mol), ethanol (3 mL), and tetrahydrofuran (3 mL) and stir overnight at ambient temperature. Remove the organic solvents in vacuo and adjust the aqueous mixture to approx. pH 3.5 with aqueous hydrochloric acid. Extract with ethyl acetate and dry the combined extracts over sodium sulfate and concentrate in vacuo. Drying nets the desired isoxazole acid as an off white solid (1.35 g, 76%). MS(FD): M+ 223.2 m/z.

후처리

  1. customRemove the organic solvents in vacuo
  2. extractionExtract with ethyl acetate
  3. dry with materialdry the combined extracts over sodium sulfate
  4. concentrationconcentrate in vacuo
  5. customDrying

출처 및 근거

ORD 기록
ord-fb9ae354fa6249f1929846597fd3dd44
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07037921B2

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