1,1-Dimethylethyl (betaS)-beta-aminobenzenepropanoate → Methyl (S)-3-amino-3-phenylpropanoate

HRID 1823833노트

반응식

HRID 1823833 반응식
[NH2:1][C@H:2]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:3][C:4]([O:6][C:7](C)(C)C)=[O:5]>Cl>[CH3:7][O:6][C:4](=[O:5])[CH2:3][C@H:2]([NH2:1])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

3

반응물 1

HCID 70210931,1-Dimethylethyl (betaS)-beta-aminobenzenepropanoate

생성물 1

HCID 788099Methyl (S)-3-amino-3-phenylpropanoate

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

t-Butyl (3S)-3-amino-3-phenylpropanoate (1.0 g, 4.97 mmol) was dissolved in methanolic hydrochloric acid (2.25M, 25 ml). The reaction mixture was heated under reflux for 3 hours, after which time the solvent was evaporated under reduced pressure and the residue basified with aqueous saturated sodium carbonate solution. The product was then extracted using dichloromethane (x2), the combined organic layers were dried (MgSO4), filtered and the solvent removed under reduced pressure to afford the title compound as a white solid, 778 mg.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 3 hours
  3. customafter which time the solvent was evaporated under reduced pressure
  4. extractionThe product was then extracted
  5. dry with materialthe combined organic layers were dried (MgSO4)
  6. filtrationfiltered
  7. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-7b7c978dde6f45a9a766c891608f96e8
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041667B1

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