2-Amino-4-methylpyridine → 2-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine

HRID 1824509

반응식

HRID 1824509 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1>C(O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 15332-Amino-4-methylpyridineHCID 74544-Bromophenacyl bromide

생성물 1

HCID 7176442-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine수율 56.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2,4′-dibromoacetophenone (22.4 g) and 2-amino-4-picoline (8.68 g) in ethanol (80 mL) was heated at reflux temperature for 3 hours. The reaction mixture was cooled to ambient temperature and the crystalline solid isolated by filtration, washed with ethanol and dried in vacuo to give the title compound (13.1 g).

후처리

  1. temperaturewas heated
  2. temperatureat reflux temperature for 3 hours
  3. customthe crystalline solid isolated by filtration
  4. washwashed with ethanol
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-5bb051e282244be59cd34ecde14aabce
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07041827B2

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