p-Cyanobenzenesulphonamide → 4-cyano-N-{3-[4-(1,2-diphenyl-but-1-enyl)-phenyl]-acryloyl}-benzenesulfonamide

HRID 1824878

반응식

HRID 1824878 반응식
[C:1]1(/[C:7](/[C:17]2[CH:22]=[CH:21][C:20]([CH:23]=[CH:24][C:25](O)=[O:26])=[CH:19][CH:18]=2)=[C:8](/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)\[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:28]([C:30]1[CH:35]=[CH:34][C:33]([S:36]([NH2:39])(=[O:38])=[O:37])=[CH:32][CH:31]=1)#[N:29]>>[C:28]([C:30]1[CH:31]=[CH:32][C:33]([S:36]([NH:39][C:25](=[O:26])[CH:24]=[CH:23][C:20]2[CH:21]=[CH:22][C:17]([C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[C:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:9][CH3:10])=[CH:18][CH:19]=2)(=[O:38])=[O:37])=[CH:34][CH:35]=1)#[N:29]

참가 물질

3

반응물 2

HCID 76566p-CyanobenzenesulphonamideHCID 30361523-[4-(Z)-(1,2-diphenylbut-1-enyl)phenyl]-acrylic acid

생성물 1

HCID 697814874-cyano-N-{3-[4-(1,2-diphenyl-but-1-enyl)-phenyl]-acryloyl}-benzenesulfonamide

실험 절차

Prepared by coupling 1a and 4-cyanobenzenesulfonamide in accordance with Procedure 1, Method B described hereinabove. Yield (21%); 1H NMR (d6-DMSO) δ 8.09–8.03 (m, 4H), 7.94 (d, J=8.0 Hz, 1H), 7.40–7.07 (m, 12H), 6.84 (d, J=8.0 Hz, 2H), 6.40 (d, J=15.7 Hz, 1H), 2.35 (q, J=7.4 Hz, 2H), 0.82 (t, J=7.4 Hz, 3H); APcI m/z: 519 (M+H+).

후처리

  1. customPrepared
  2. customYield (21%)

출처 및 근거

ORD 기록
ord-5e33c4f5736f4876991d1d07c2c1209e
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07045540B2

연결된 노트

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