Hydrochloric Acid → (R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

HRID 1825044노트

반응식

HRID 1825044 반응식
C(OC(=O)[NH:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10])(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH2:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57419701(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester

생성물 1

HCID 57462036(R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester (2.5 g) and 9 mL of 4 N HCl in ethyl acetate at 50° C. was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the title compound (1.2 g) as a solid which was used in the next step without further purification.

후처리

  1. concentrationAfter concentration
  2. extractionextracted with methylene chloride
  3. washThe organic layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-062f6ba3c58045ff9ccff54ef3a87135
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07045551B2

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