Hydrochloric Acid → {2-[(6-Amino-5-nitro(2-pyridyl))amino]ethyl}[4-(2,4-dichlorophenyl)-5-piperazinylpyrimidin-2-yl]amine

HRID 1825457노트

반응식

HRID 1825457 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=3[Cl:25])[C:15]([N:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]3)=[CH:14][N:13]=2)[CH:5]=[CH:4][C:3]=1[N+:39]([O-:41])=[O:40].Cl>CO>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=3[Cl:25])[C:15]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[CH:14][N:13]=2)[CH:5]=[CH:4][C:3]=1[N+:39]([O-:41])=[O:40]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22142685Tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

생성물 1

HCID 18334985{2-[(6-Amino-5-nitro(2-pyridyl))amino]ethyl}[4-(2,4-dichlorophenyl)-5-piperazinylpyrimidin-2-yl]amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1 mmol of tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate was heated to 60° C. 3M HCl in MeOH for one hour and concentrated in vacuo to obtain{2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[4-(2,4-dichlorophenyl)-5-piperazinylpyrimidin-2-yl]amine.

후처리

  1. concentrationconcentrated in vacuo to obtain{2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[4-(2,4-dichlorophenyl)-5-piperazinylpyrimidin-2-yl]amine

출처 및 근거

ORD 기록
ord-cd2aaf095f2c4b1cb6220e31cc3bc905
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07045519B2

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