Hydrochloric Acid → 3-Benzoylpropionitrile

HRID 1825900

반응식

HRID 1825900 반응식
Br[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[C:12]([Cu])#[N:13].Cl>CN(C=O)C.O>[C:12]([CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5])#[N:13]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 1224323-Bromo-1-phenylpropan-1-oneHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 1384653-Benzoylpropionitrile

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

Based on Kulkarni, N. R. Ayyangar, Tetrahedron, 1994, 50, 1243–1260. ]: A mixture of 3-bromopropiophenone (10.65 g, 50 mmol), CuCN (5.82 g, 65 mmol) in DMF (35 mL) was heated under reflux for 6 h. After cooling the mixture to ambient temperature FeCl3 (5 g) in H2O (30 mL)/HCl conc (10 mL) was added and heated to 80° C. for another 20 min. After cooling to room temperature and extraction with ether further purification occurred by destination under reduced pressure (bp.: 140° C., 10 torr). The ketone could be obtained as slightly yellow, low melting (42° C.) solid.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 6 h
  3. additionwas added
  4. temperatureAfter cooling to room temperature
  5. extractionextraction
  6. customwith ether further purification

출처 및 근거

ORD 기록
ord-1c2f071980d9481e835ff442b85d516c
출처 데이터셋
uspto-grants-2006_05
특허 번호
US07049332B2

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